1. To push or lean against someone or something. There's a big piece of sheet metal pressing against the door we're trying to get open. Stop pressing against me, would you? You need to wait your turn like everyone else.

2. To push or lean someone or something against another person or thing. In this usage, a noun or pronoun is used between "press" and "against." She pressed him against the door and leaned in for a kiss. He just kept pressing his fingers against the side of his head. Please don't press your feet against me like that.