1. Literally, to accept Jesus Christ as one's savior. An inspirational homily sparked my come to Jesus moment, and I've been a Christian ever since.

2. A phrase used to describe a persuasive conversation aimed at getting the listener to change (and, often, to stop doing something negative or self-destructive). When my parents found out that Jack was doing drugs, they sat him down for a come to Jesus talk, in the hopes that they could get him to agree to rehab. After months of poor performance, the boss is calling Janet in for a come to Jesus meeting.