what's up with (someone)
1. What is new in someone's life? Oh, hey Jim, what's up with you? Did you end up getting that job in Denver?
2. Is there something wrong with someone? Is someone OK? Why is someone upset? Wow, what's up with Cheryl today? She seems like she's in a really bad mood. I'll tell you what's up with me: I'm really annoyed at you for leaving all these dishes for me to clean up, instead of just doing them yourself!