1. To leave or depart from someone or something. It is always terrible having to part from the children when I travel for work. The billionaire announced that he had parted from the company he helped to establish.

2. To separate someone from someone else; to take a person away from someone. In this usage, a noun or pronoun is used between "part" and "from." The earthquake has parted many from their families as transportation services continue to be out of service. The job parted me from my family for months at a time.