To prevent the inclusion of someone or something in something; to leave someone or something out of something. Kyle isn't coming to the party after all, so exclude him from your head count. Exclude pens from your supply orders for a little while because we're fully stocked on them.

Without regards to the person or people in one's immediate vicinity. Everyone in this school is a self-centered, spoiled little brat. Present company excluded, of course. Present company excluded, there isn't a single person in this building who has the skills it takes to run the business.