1. To greatly irritate or annoy one, especially to the point of affecting their nerves. Nothing makes my teeth itch like seeing these cyclists run every red light in town! I don't know what it is about Terry, but there's something about his demeanor that just makes my teeth itch!

2. To cause one to be especially upset, nervous, or uncomfortable. Please don't tell me about your surgery—it makes my teeth itch hearing about blood and gore.