1. slang Someone who frequently or habitually uses or abuses drugs prepared as pills or capsules. She started getting hooked on the pain pills her doctor prescribed, and before long she had become a full-blown popper. I knew a couple of poppers in college who were always doing speed or ecstasy.

2. slang A capsule or ampoule containing one of a range of alkyl nitrites, most commonly amyl nitrite, that is inhaled recreationally to produce euphoria and to enhance sexual pleasure. Typically used in plural constructions. Everyone I knew was doing poppers back when I was in college, and no one really considered it a problem. I mean, back then you could buy them legally, after all. He said he used the stuff to treat his angina, but I think he just like snorting poppers at parties to feel high.