1. slang A particularly muscular arm; an arm's large bicep. Usually used in the plural in reference to both arms or both sets of biceps. He always wears tank tops so he can show off his pythons. I caught her flexing her pythons in front of the mirror after her workout.

2. vulgar slang A penis. Excuse me a minute. After all those beers, I need to go siphon the python. I asked her if she wanted to feel my python, and she slapped me right in the face.