1. To be deceased. My poor old dad has been toes up for five years today, but I still miss him like crazy! When I'm toes up, I don't want my funeral to be a somber occasion—I want people to smile and remember the good times we all had together!

2. To be completely non-functioning, non-operational, incapacitated, or destroyed. It looks like after nearly 80 years of struggling to stay open, the family business is going to be toes up very shortly. I'm just writing this email to let you know that your website has been toes up for the last 12 hours or so.