To have no faith, confidence, or belief in someone or something; to not care about, appreciate, or respect someone or something. I, however, set no store by promises of the afterlife, so I have learned to enjoy my time here to the utmost. I'm afraid my brother should be kept off the list of guests, as he sets no store by obeying social rules or etiquette. My wife sets no store by me ever since she caught me cheating on her.