1. Literally, to grasp one's hand and continue holding it, typically while walking together or sitting next to each other, often as a show of affection. I think it's so sweet how Jenny holds Tim's hand when they walk into school.

2. To comfort or support one when they are frightened, anxious, or distressed. I know you're worried about giving your speech, but I'll be there to hold your hand.

3. To carefully guide one through something; to make something very easy for one. Thank you, but I can figure these problems out myself without you holding my hand. The video game is brutally difficult, and it doesn't hold the player's hand at any point.