In, related to, or matching someone's general interests, abilities, or area of familiarity; in someone's comfort zone. It's clear, however, that the political implications of this issue are well in the author's wheelhouse. Jeff's always stayed in his wheelhouse when it comes to dating women. He doesn't usually go for anyone very different from himself.

Against, outside of, or not matching someone's general interests, abilities, or area of familiarity; outside of someone's comfort zone. It's clear, however, that the political implications of this issue are well outside the author's wheelhouse. Jeff generally doesn't date women outside of his wheelhouse. You need to get out of your wheelhouse and live on the wild side for a change!