tie (someone) in(to) knots
To make someone confused, anxious, worried, and/or upset. I've been planning on proposing to James on Sunday, but the nervousness is tying me into knots! It's something about the austere way the boss talks that always ties you into knots.
tie someone (up) in knots
Fig. to become anxious or upset. John tied himself in knots worrying about his wife during her operation. This waiting and worrying really ties me up in knots.