To be offended, upset, or negatively affected by something at a personal level; to consider something as being a direct, personal attack against oneself. Don't take his comments personally—he's that hard on everyone in the office. I know these comments are all from anonymous people on the internet that I'll never meet, but it's still hard not to take them personally. I'm just afraid that all these people we're not inviting to the wedding will take it personally.