1. Literally, to use some instrument to hit or smash into someone or something. In this usage, a noun or pronoun is used between "strike" and "on." The child struck her dad with the toy hammer just like she saw in the cartoon. The driver struck the building with his car at nearly 60 miles per hour. The defendant was struck with rocks and rotting produce as he left the courtroom this afternoon.

2. To overwhelm someone or something with some sudden and powerful ailment, impairment, or emotion. Often used in passive constructions. The announcement struck us with shock and bewilderment, though those two emotions were soon replaced with anger and sadness. He's been stricken with a debilitating disease of the immune system for the last five years. The stock market was stricken with a severe downturn over the weekend following speculation of the country's exit from the customs union.