1. To strike or inflict a heavy blow on someone or something with something. Chiefly found in fantasy literature. The dragon smote the mighty castle with blasts of white-hot fire from its mouth. The farmer set about smiting the vagrant with the handle of a broom after he was caught stealing crops.

2. To afflict someone or something with some physical, mental, or emotional condition. Almost exclusively used in passive constructions, except in biblical writings. The entire office has become smitten with the 'flu. God smote the land of Egypt with ten plagues.

3. To make a very favorable impression on someone; to enamor someone. Almost exclusively used in passive constructions. The whole of the assembly was positively smitten with the precocious young child who had dazzled them with such a marvelous display of skill and wit. Mary has always been smitten with you, John. Please try to talk some sense into her.