1. To make someone or something more inclined to some action in advance. Often used in passive constructions. Harvard's reputation for its law program predisposed him to go there after high school. I know Ruth is predisposed to do whatever her father suggests due to her overwhelming sense of loyalty to him.

2. To make someone or something more susceptible or liable to something. Often used in passive constructions. It's your mother's father who predisposes you to baldness, not your own father. My genetics predispose me to heart disease, so I take every precaution I can to avoid it. The economy was already predisposed to collapse due to the sudden removal of many regulations that kept it in balance.