1. To pop one's head up, especially from below or behind something or some surface, in a manner resembling a prairie dog emerging from its burrow. Everyone started prairie dogging in their cubicles to see where the music was coming from. The puppy prairie dogged the moment she heard the bag of treats being opened.

2. vulgar slang To need to defecate so badly that one's feces begin to come out through the anus involuntarily. I need to find a bathroom now—I'm starting to prairie dog! I was prairie dogging it by the time we finally got to a rest stop.