1. To cause a lot of serious issues or disruptions for someone or something. The road closures have raised the dickens with rush-hour traffic. The blizzard is raising the dickens with travelers flying in and out of the region.

2. To make a lot of angry, vocal complaints with someone or some group, department, organization, etc. There's been one customer raising the dickens with our customer service team for the last week over some issue with his software. The problem isn't going to go away on its own—you need to go raise some the dickens with your boss or the head of HR.