(one's) number is up
It is one's time to die, suffer, or be punished. My only wish is that I don't feel any pain when my number is up. This evidence proves that the senator was part of the conspiracy. His number's up this time.
one's number is up
Fig. one's time to die—or to suffer some other unpleasantness—has come. John is worried. He thinks his number is up. When my number is up, I hope it all goes fast.