To cause something to become dirtied, contaminated, or impure as a result of the introduction of something. People have been polluting this river with garbage and raw sewage for so long that it has become toxic. I just don't understand how people could pollute their bodies and minds with drugs and alcohol like that.

slang Heavily intoxicated with drugs or alcohol. I was so polluted I couldn't even write my name legibly. My father used to spend all weekend too polluted to play with me or my siblings.