To have faith, confidence, or belief in someone or something; to care about, appreciate, or respect someone or something. I, however, have set store in the promise of the afterlife, so I choose to lead my life piously and devoutly. I'm afraid my brother should be kept off the list of guests, as he's not one to set great store in obeying social rules or etiquette. It's important to have close friends in life that you may set store in when times are tough.