A rude and angry expression of disgust or dissatisfaction with someone or something, especially indicating that one doesn't want to be associated with the person or do the thing in question. A: "The manager said all staff have to be in tomorrow at 6 AM to help with the stock check." B: "Screw that! There's no way I'm coming in that early!" She treated you like garbage, and now she expects you to help her with the business? Screw her!