American to have a strong wish to do something and to not allow anything to stop you from doing it.
She's bound and determined to make her career in medical research.
(often + to do something)
be bound and determined
To be very focused on completing a particular task or goal. My brother has been practicing all summer because he's bound and determined to make the basketball team this year.I am bound and determined to lose weight, so please don't bring any sweets into the house.