1. slang To be or become particularly excited by or enthusiastic about something, especially in, or likened to, a sexual manner. It seems like Kaya gets off on the power of her new corporate management role. I don't know why you get off on going to the gym every day—it just seems like a chore to me!

2. slang To become high from taking a particular drug. I guess I don't inhale well because I never seem to get off on pot.