How are things going?
1. How are you? An informal greeting. Hey, great to see you again! How are things going? Hi Murray, how're things going?
2. How is (something) proceeding or progressing? You're working on the Smith case, right? How are things going?
How are things (with you)?
How are you? An informal greeting. Hey, great to see you again! How are things? Hi Murray, how're things with you?