In most instances; usually; at least, if not more than, half the time. As often as not, Jamie's and David's debates end up turning into petty arguments. I find these introductory college courses to be, often as not, a rather boring waste of one's time.

Frequently; more than half the time. The phrase is not always preceded by the adverb "as." As often as not, I end up disliking coming back to my hometown for a visit. I'll have a drink with dinner often as not.