To make or become more lively, energetic, attentive, cheerful, dynamic, etc. I wish you would perk up. There are so many exciting things happening, and you're just moping there in the corner! I think I need some coffee to perk me up. I always use some red chilies to perk up my soups and stews.

Stimulated; made to be or feel more awake, alert, and energetic. Hyphenated if used before a noun. I just can't focus until I get perked up with a bit of coffee in the morning. The officer suspected that the perked-up truck driver might have been high on amphetamines.