To be able to consume alcohol without becoming noticeably intoxicated or exhibiting other negative effects, such as becoming ill or unconscious. To have a high tolerance for alcohol. I'm sorry for acting like such a fool at the party—I don't even remember what happened. I guess I just can't hold my liquor. A: "Wow, Jennifer has had five cocktails and still seems totally sober." B: "Oh yeah, that girl can hold her liquor."