1. Of a path or route, to continue or end up out of something or some place. This trail should lead out of the forest and back to the parking lot. That's the highway leading out of New York.

2. To guide or direct someone or an animal out of something or some place. In this usage, a noun or pronoun is used between "lead" and "out." We've got to lead the herd out of the valley before this storm hits. Firefighters began leading people out of the burning building.